Posts Tagged Nathalia Holt

notable Boston-area book readings in February 2017

bishop

Megan Marshall
Elizabeth Bishop: A Miracle for Breakfast
Harvard Book Store
Tuesday, February 7 at 7pm

30753707
Michael Bennett, MD and Sarah Bennett
F*ck Love
Brookline Booksmith
Tuesday, February 7 at 7pm

really-good-day

Ayelet Waldman
A Really Good Day
Brookline Booksmith
Wednesday, February 8 at 7pm

harvester

John Darnielle
Universal Harvester
Harvard Book Store
at Brattle Theatre
Wednesday, February 8 at 6pm

american-hookup

Lisa Wade
American Hookup: The New Culture of Sex on Campus
Harvard Book Store
Thursday, February 9 at 7pm

pachinko

Min Jin Lee
Pachinko
Harvard Book Store
Friday, February 10 at 7pm

stand-your-ground

Caroline Light
Stand Your Ground: A History of America’s Love Affair with Lethal Self-Defense
Harvard Book Store
Thursday, February 16 at 7pm

lipman

Elinor Lipman
On Turpentine Lane
Brookline Booksmith
Thursday, February 16 at 7pm

difficult-women

Roxane Gay
Difficult Women
Porter Square Books
Friday, February 17 at 7pm

stolen-child

Lisa Carey
The Stolen Child
Brookline Booksmith
Saturday, February 18 at 7pm

news from the end of the world.jpg

Emily Jeanne Miller
The News from the End of the World
Harvard Book Store
Tuesday, February 21 at 7pm

bucky-dent

David Duchovny
Bucky F*cking Dent
Brookline Booksmith
Wednesday, February 22 at 12pm

bishop

Megan Marshall
Elizabeth Bishop: A Miracle for Breakfast
Brookline Booksmith
Wednesday, February 22 at 7pm

rise of the rocket girls

Nathalia Holt
Rise of the Rocket Girls: the Women Who Propelled Us, from Missiles to the Moon to Mars
WorkBar Cambridge
Monday, February 27 at 6:30pm

girl-at-baggage

Gish Jen
The Girl at the Baggage Claim: Explaining the East-West Culture Gap
Harvard Book Store
Tuesday, February 28 at 7pm

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Boston-area book readings of note in April

rise of the rocket girls

Nathalia Holt
Rise of the Rocket Girls
Brookline Booksmith
Tuesday, April 5 at 7pm

modern girls

Jennifer Brown
Modern Girls
Porter Square Books
Wednesday, April 6 at 7pm

security mom

Juliette Kayyem
Security Mom
Harvard Book Store
Thursday, April 7 at 7pm

incarceration nations

Baz Dreisinger
Incarceration Nations
Brookline Booksmith
Wednesday, April 13 at 7pm

luckiest girl alive

Jessica Knoll
Luckiest Girl Alive
Brookline Booksmith
Monday, April 25 at 7pm

the good death

Ann Neumann
The Good Death: An Exploration of Dying in America
Harvard Book Store
Tuesday, April 26 at 7pm

last bookaneer

Matthew Pearl
The Last Bookaneer
Brookline Booksmith
Tuesday, April 26 at 7pm

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STEELE PICKS: 10 BEST NONFICTION BOOKS of 2014

art of asking

1. The Art of Asking by Amanda Palmer [Grand Central Publishing]

–As a feminist and a Boston-based music journalist, I love everything about this memoir. It’s absolutely engrossing. I liked Boston’s The Dresden Dolls and always appreciated Amanda Palmer for her outspoken nature, her feminism and musicianship. Now I truly admire Amanda Palmer and feel we’d be friends if we ever met. I’m wondering if we were ever at a party at the same time at Castle von Buhler—my artist friend Cynthia von Buhler’s former Boston home. The Art of Asking illustrates the importance of making lasting connections through art, love and creativity.

complete review

JoannaSmithRakoff.jacket

2. My Salinger Year by Joanna Rakoff [Knopf]

–Everything about this memoir appeals to me from the font to the cover to the 90s setting to the tone. It begins in winter with sections by season, then chapters with titles such as “Three Days of Snow,” “The Obscure Bookcase,” “Sentimental Education” and “Three Days of Rain.” Memoir as literary recollections. It’s lovely and immensely engrossing because we’ve all experienced periods of doubt, periods of reflection, periods of development, our twenties or the 90s (for some of us, our twenties and the nineties were all of that).

complete review

working-stiff-cover-199x300

3. Working Stiff by Judy Melinek [Scribner]

–a medical examiner’s residency in New York. detailed, gory and completing engrossing.

Cured

4. Cured by Nathalia Holt [Dutton]

–Berlin patients. painstakingly researched and explained.

interview with Nathalia Holt

unspeakable things

5. Unspeakable Things by Laurie Penny [Bloomsbury USA]

review

alice and freda forever

6. Alice + Freda Forever by Alexis Coe [Pulp]

review

mainardi_thefall-final

7. The Fall by Diogo Mainardi [Other Press]

–This is a love story. A moving, clever memoir about a father’s relationship with his son Tito, born with cerebral palsy. It’s clever because Mainardi writes in 424 steps like the steps that his son has progressively taken over the years as he grows stronger and more confident in his movement. A poet and journalist, Mainardi writes lyrically as well as in a scrupulously researched manner. It’s beautiful and fascinating.

review

cover_bad_feminist

8. Bad Feminist by Roxanne Gay [Harper]

review

being mortal

9. Being Mortal by Atul Gawande [Metropolitan Books]

–so much respect for Dr. Atul Gawande and his ability delve into particular medical issues, like aging and death, that prove difficult to discuss. thoughtful text and interesting case studies.

roz chast

10. Can We Talk About Something More Pleasant? by Roz Chast [Bloomsbury USA]

–amusing and sad: appropriate in describing the aging process.

“I wish that, at the end of life, when things were truly “done,” there was something to look forward to. Something more pleasure-oriented. Perhaps opium or heroin. So you became addicted. So what? All-you-can-eat ice cream parlors for the extremely aged. Big art picture books and music. Extreme palliative care, for when you’ve had it with everything else: the x-rays, the MRIs, the boring food and the pills that don’t do anything at all. Would that be so bad?”

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IN THE REALM: BEST BOOKS of 2014 [SO FAR]

daring ladies of lowell

The Daring Ladies of Lowell by Kate Alcott
–Lowell mill girls. a murder. riveting historical fiction.

everything i never

Everything I Never Told You by Celeste Ng
–heartbreaking exploration on race and identity in the 1970s.

JoannaSmithRakoff.jacket

My Salinger Year by Joanna Rakoff
–Rakoff makes her memoir about a year working at a literary agency in New York heartwarming, relatable and intriguing through exquisite writing.

fallout

Fallout by Sadie Jones
–fell in love with this book about a group of 20-somethings entangled with the theatre and each other’s lives in 1970s London.

boy snow bird

Boy, Snow, Bird by Helen Oyeyemi
–stunning re-telling of a fairytale and examination of race.

visible city

Visible City by Tova Mirvis
–cool writing, intriguing premise. reflection on connectivity, relationships and urban dwelling.

pioneer girl

Pioneer Girl by Bich Minh Nguyen
–another wonderful novel about race. this time a young woman’s connection to Laura Ingalls Wilder via Vietnam.

Cured

Cured by Nathalia Holt
–Berlin patients. painstakingly researched and explained.

fallen beauty

Fallen Beauty by Erika Robuck
–Robuck imagines the connection between poet Edna St. Vincent Millay and a seamstress in her small town. Robuck conducted impeccable research and allowed Millay’s vibrant spirit, sensuality and creative force to come forth on the page.

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STEELE INTERVIEWS: author Nathalia Holt [CURED]

Cured

Growing up in Manhattan, Nathalia Holt interned at a hospital in Hell’s Kitchen as a teenager in the 90s. It had a really large AIDs ward. “As a teenager it really touched me, it stayed with me.” She almost always knew she wanted to be a scientist and ended up majoring in molecular biology in college and then earning her PhD. She completed her dissertation on HIV gene therapy. Holt is an award-winning research scientist specializing in HIV biology. She trained at the Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, the University of Southern California and Tulane University. CURED is about the Berlin patients, two patients diagnosed with HIV who became cured through two vastly different treatment plans.

Amy Steele: Why did you want to write this book?

Nathalia Holt: I was really struck by how few people had heard of the Berlin patients. It’s such a big story for HIV researchers and those living with HIV. It’s a great. I really wanted to bring this story about somehow. It’s a story you’d not expect.

Amy Steele: Can you explain the Berlin patient?

Nathalia Holt: There are two Berlin patients. One of them [known by the identity Christian Hahn] received this really aggressive therapy from a family doctor in Berlin. And he got cleared of the virus and his case has inspired a lot of cases of eradication of the virus using early aggressive therapies. The second Berlin patient who is Timothy Ray Brown had cancer and HIV. He was given a stem cell transplant from a person who is naturally resistant to HIV. There’s this small group of people who are naturally able to control their HIV because they have a gene mutation that locks HIV out of their cells. So once he got this stem cell transplant it cleared HIV out of his body. He’s inspired many clinical trials, most prominently, gene therapy trials that have a lot of promise right now.

Nathalia Holt (photo by Steph Stevens)

Nathalia Holt (photo by Steph Stevens)

Amy Steele: How are the Berlin cases important to and the importance to HIV research?

Nathalia Holt: These cases have changed how HIV cases are funded. Cases are directly cited. Last December $100 million grant by Obama for HIV research [ HIV Cure initiative in honor of the 25th World Aids Day launched by Obama administration]. These cases have changed the culture of talking about HIV research and have opened up the funding and way to collect data. Funding agencies that never would have funded before now cite these cases. They’ve changed the culture. They’ve ended up influencing some really big cases. In Timothy’s case, there’s gene therapy in recreating mutations in people’s own cells which may really work. And now we have these pediatric cases. Treat HIV early and aggressively and clear the virus early of these kids. It’s a matter of getting the testing and formulations and bringing it to a bigger scale.

Amy Steele: You’ve said that the medical community and researchers don’t like to talk about a cure. You talked about the difference between a functional and a sterilizing cure and yet you titled your book CURED. Why?

Nathalia Holt: Previously you didn’t want to talk about a cure. It had a terrible reputation. It’s completely changed now. I was at a big HIV meeting last week and there was a Cure symposium. It’s really such an incredible turnaround. When I think about five years ago at the same meeting and what it’s like today, it could not be more different. People are very comfortable using this cure word when talking about HIV. And I feel very comfortable talking about these patients being cured.

Amy Steele: What makes a retrovirus?

Nathalia Holt: It’s made of RNA. How they’re really sneaky is that they can integrate into our own DNA. They package their own genetic material and hide it in our genetic material. They basically turn our cells against us and make a virus that way. It’s why it’s so difficult to treat [HIV]. It is able to hide so well in the body.

Amy Steele: You said that the gut not the blood contains “vast majority of the body’s immune system, more than 70 percent of all T cells reside there not in our blood.” How is this important?

Nathalia Holt: For so many years people were focused on the blood because it’s so much easier to sample the blood and filter the blood. Yet this is the tissue where you have all these cells that HIV loves that are all packed together. And you also have these long-lived cells in the gut for HIV to hide. So it’s important to remember these anatomical sites that you wouldn’t consider otherwise.

Amy Steele: How is gene therapy more effective than other types of therapy? Can you explain the importance of the CCR5 gene?

Nathalia Holt: You can draw blood from a person with HIV and then you can isolate out the cells and make cuts in the CCR5 gene, the same gene that people who have this mutation this gives them a natural resistance (to HIV). And because they have this mutation in this gene, HIV can’t enter their cells. So after you modify their cells you’re able to put them back into the same patients and they hone to the body, to the bone marrow and become part of this next generation of cells that are resistant to HIV. And more than that they have a selective advantage.

Amy Steele: You did a great job describing the personal lives of the Berlin patients are. Sounds like Timothy’s doing a lot of speaking engagements.

Nathalia Holt: He’s doing much better. He has a new living situation and a new boyfriend. He’s so much better and so much happier.

Amy Steele: He had so many other things going on besides HIV.

Nathalia Holt: He had three rounds of chemo. He had kidney failure. It’s just the toll of having multiple brain biopsies, a stem cell transplant. I think anyone would be knocked down for a while. It’s good that he’s coming back now and feeling better.

Amy Steele: Both Christian Hahn and Timothy Brown still consider themselves to be HIV positive although essentially cured of it.

Nathalia Holt: I really thought this was an interesting thing. Somehow having the virus has this identity of its own.

Amy Steele: One thing I took away from the few semesters of nursing school and becoming a medical assistant is that every medication has side effects and no medication is 100% effective. It’s intriguing in any study how individual it becomes.

Nathalia Holt: These physicians tailored therapy just for them and not for anyone else. It was made very thoughtfully by their physicians. And it says so much for primary care.

purchase at Amazon: Cured: How the Berlin Patients Defeated HIV and Forever Changed Medical Science

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